LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction

Mutations in the protein LRRK2 have been associated with Parkinson's disease but little is still known about the basic functions of the protein in the brain. Here the authors show that in fruit flies, LRRK2 regulates retrograde homeostatic synaptic compensation at the larval neuromuscular junct...

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Autores principales:	Jay Penney, Kazuya Tsurudome, Edward H. Liao, Grant Kauwe, Lindsay Gray, Akiko Yanagiya, Mario R. Calderon, Nahum Sonenberg, A. Pejmun Haghighi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/28b871da68c441029f3092bf68c4f2c8
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spelling	oai:doaj.org-article:28b871da68c441029f3092bf68c4f2c82021-12-02T17:33:20ZLRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction10.1038/ncomms121882041-1723https://doaj.org/article/28b871da68c441029f3092bf68c4f2c82016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12188https://doaj.org/toc/2041-1723Mutations in the protein LRRK2 have been associated with Parkinson's disease but little is still known about the basic functions of the protein in the brain. Here the authors show that in fruit flies, LRRK2 regulates retrograde homeostatic synaptic compensation at the larval neuromuscular junction.Jay PenneyKazuya TsurudomeEdward H. LiaoGrant KauweLindsay GrayAkiko YanagiyaMario R. CalderonNahum SonenbergA. Pejmun HaghighiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jay Penney Kazuya Tsurudome Edward H. Liao Grant Kauwe Lindsay Gray Akiko Yanagiya Mario R. Calderon Nahum Sonenberg A. Pejmun Haghighi LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction
description	Mutations in the protein LRRK2 have been associated with Parkinson's disease but little is still known about the basic functions of the protein in the brain. Here the authors show that in fruit flies, LRRK2 regulates retrograde homeostatic synaptic compensation at the larval neuromuscular junction.
format	article
author	Jay Penney Kazuya Tsurudome Edward H. Liao Grant Kauwe Lindsay Gray Akiko Yanagiya Mario R. Calderon Nahum Sonenberg A. Pejmun Haghighi
author_facet	Jay Penney Kazuya Tsurudome Edward H. Liao Grant Kauwe Lindsay Gray Akiko Yanagiya Mario R. Calderon Nahum Sonenberg A. Pejmun Haghighi
author_sort	Jay Penney
title	LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction
title_short	LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction
title_full	LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction
title_fullStr	LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction
title_full_unstemmed	LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction
title_sort	lrrk2 regulates retrograde synaptic compensation at the drosophila neuromuscular junction
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/28b871da68c441029f3092bf68c4f2c8
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LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction

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