The heavy chain of 4F2 antigen promote prostate cancer progression via SKP-2

The heavy chain of 4F2 antigen promote prostate cancer progression via SKP-2

Abstract The 4F2 cell-surface antigen heavy chain (4F2hc) forms a heterodimeric complex with L-type amino acid transporter 1 (LAT1) and transports large neutral essential amino acids. However, in contrast to the traditional role of LAT1 in various cancers, the role of 4F2hc has largely remained unkn...

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Main Authors: Maihulan Maimaiti, Shinichi Sakamoto, Masahiro Sugiura, Manato Kanesaka, Ayumi Fujimoto, Keisuke Matsusaka, Minhui Xu, Keisuke Ando, Shinpei Saito, Ken Wakai, Yusuke Imamura, Keiichi Nakayama, Yoshikatsu Kanai, Atsushi Kaneda, Yuzuru Ikehara, Jun-Ichiro Ikeda, Naohiko Anzai, Tomohiko Ichikawa
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/29192c71cd4c466db76e5d10cfc62d81
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https://doaj.org/article/29192c71cd4c466db76e5d10cfc62d81

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