Bi-directional ribosome scanning controls the stringency of start codon selection

Start codon selection is commonly thought to occur through the unidirectional scanning of the mRNA by the 40 S ribosome. Here the authors provide evidence that the pre-initiation complex can backslide on the mRNA to initiate translation at upstream AUG codons.

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Auteurs principaux: Yifei Gu, Yuanhui Mao, Longfei Jia, Leiming Dong, Shu-Bing Qian
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Q
Accès en ligne:https://doaj.org/article/291d39793d7a4dbc85968755a40300d0
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