Bi-directional ribosome scanning controls the stringency of start codon selection

Start codon selection is commonly thought to occur through the unidirectional scanning of the mRNA by the 40 S ribosome. Here the authors provide evidence that the pre-initiation complex can backslide on the mRNA to initiate translation at upstream AUG codons.

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Autores principales:	Yifei Gu, Yuanhui Mao, Longfei Jia, Leiming Dong, Shu-Bing Qian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/291d39793d7a4dbc85968755a40300d0
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spelling	oai:doaj.org-article:291d39793d7a4dbc85968755a40300d02021-11-21T12:34:30ZBi-directional ribosome scanning controls the stringency of start codon selection10.1038/s41467-021-26923-32041-1723https://doaj.org/article/291d39793d7a4dbc85968755a40300d02021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26923-3https://doaj.org/toc/2041-1723Start codon selection is commonly thought to occur through the unidirectional scanning of the mRNA by the 40 S ribosome. Here the authors provide evidence that the pre-initiation complex can backslide on the mRNA to initiate translation at upstream AUG codons.Yifei GuYuanhui MaoLongfei JiaLeiming DongShu-Bing QianNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yifei Gu Yuanhui Mao Longfei Jia Leiming Dong Shu-Bing Qian Bi-directional ribosome scanning controls the stringency of start codon selection
description	Start codon selection is commonly thought to occur through the unidirectional scanning of the mRNA by the 40 S ribosome. Here the authors provide evidence that the pre-initiation complex can backslide on the mRNA to initiate translation at upstream AUG codons.
format	article
author	Yifei Gu Yuanhui Mao Longfei Jia Leiming Dong Shu-Bing Qian
author_facet	Yifei Gu Yuanhui Mao Longfei Jia Leiming Dong Shu-Bing Qian
author_sort	Yifei Gu
title	Bi-directional ribosome scanning controls the stringency of start codon selection
title_short	Bi-directional ribosome scanning controls the stringency of start codon selection
title_full	Bi-directional ribosome scanning controls the stringency of start codon selection
title_fullStr	Bi-directional ribosome scanning controls the stringency of start codon selection
title_full_unstemmed	Bi-directional ribosome scanning controls the stringency of start codon selection
title_sort	bi-directional ribosome scanning controls the stringency of start codon selection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/291d39793d7a4dbc85968755a40300d0
work_keys_str_mv	AT yifeigu bidirectionalribosomescanningcontrolsthestringencyofstartcodonselection AT yuanhuimao bidirectionalribosomescanningcontrolsthestringencyofstartcodonselection AT longfeijia bidirectionalribosomescanningcontrolsthestringencyofstartcodonselection AT leimingdong bidirectionalribosomescanningcontrolsthestringencyofstartcodonselection AT shubingqian bidirectionalribosomescanningcontrolsthestringencyofstartcodonselection
_version_	1718418874261569536

Bi-directional ribosome scanning controls the stringency of start codon selection

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