A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy

A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy

The neural circuits through which the substantia nigra pars reticulata (SNr) exerts its role in epilepsy control are not known. Here the authors reveal that a long-range SNr-parafascicular nucleus disinhibitory circuit participates in regulating seizures in temporal lobe epilepsy and inhibition of t...

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Main Authors: Bin Chen, Cenglin Xu, Yi Wang, Wenkai Lin, Ying Wang, Liying Chen, Heming Cheng, Lingyu Xu, Tingting Hu, Junli Zhao, Ping Dong, Yi Guo, Shihong Zhang, Shuang Wang, Yudong Zhou, Weiwei Hu, Shuming Duan, Zhong Chen
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
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Online Access:https://doaj.org/article/29241ff20df247bfae9f0ed1d9d0bb7a
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