Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

The molecular mechanisms underpinning how fasting inhibits tumourigenesis are not completely elucidated. Here, the authors show that fasting upregulates the cholesterogenic gene FDFT1 which leads to decreased AKT/mTOR/HIF1a signalling and glycolysis reduction in colorectal cancer.

Saved in:
Bibliographic Details
Main Authors: Mei-lin Weng, Wan-kun Chen, Xiang-yuan Chen, Hong Lu, Zhi-rong Sun, Qi Yu, Peng-fei Sun, Ya-jun Xu, Min-min Zhu, Nan Jiang, Jin Zhang, Jian-ping Zhang, Yuan-lin Song, Duan Ma, Xiao-ping Zhang, Chang-hong Miao
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
Q
Online Access:https://doaj.org/article/292783a4478044e7aa00b20a1e94ff4e
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/292783a4478044e7aa00b20a1e94ff4e

Similar Items