Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

The molecular mechanisms underpinning how fasting inhibits tumourigenesis are not completely elucidated. Here, the authors show that fasting upregulates the cholesterogenic gene FDFT1 which leads to decreased AKT/mTOR/HIF1a signalling and glycolysis reduction in colorectal cancer.

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Autores principales:	Mei-lin Weng, Wan-kun Chen, Xiang-yuan Chen, Hong Lu, Zhi-rong Sun, Qi Yu, Peng-fei Sun, Ya-jun Xu, Min-min Zhu, Nan Jiang, Jin Zhang, Jian-ping Zhang, Yuan-lin Song, Duan Ma, Xiao-ping Zhang, Chang-hong Miao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/292783a4478044e7aa00b20a1e94ff4e
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spelling	oai:doaj.org-article:292783a4478044e7aa00b20a1e94ff4e2021-12-02T17:32:29ZFasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression10.1038/s41467-020-15795-82041-1723https://doaj.org/article/292783a4478044e7aa00b20a1e94ff4e2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15795-8https://doaj.org/toc/2041-1723The molecular mechanisms underpinning how fasting inhibits tumourigenesis are not completely elucidated. Here, the authors show that fasting upregulates the cholesterogenic gene FDFT1 which leads to decreased AKT/mTOR/HIF1a signalling and glycolysis reduction in colorectal cancer.Mei-lin WengWan-kun ChenXiang-yuan ChenHong LuZhi-rong SunQi YuPeng-fei SunYa-jun XuMin-min ZhuNan JiangJin ZhangJian-ping ZhangYuan-lin SongDuan MaXiao-ping ZhangChang-hong MiaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mei-lin Weng Wan-kun Chen Xiang-yuan Chen Hong Lu Zhi-rong Sun Qi Yu Peng-fei Sun Ya-jun Xu Min-min Zhu Nan Jiang Jin Zhang Jian-ping Zhang Yuan-lin Song Duan Ma Xiao-ping Zhang Chang-hong Miao Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression
description	The molecular mechanisms underpinning how fasting inhibits tumourigenesis are not completely elucidated. Here, the authors show that fasting upregulates the cholesterogenic gene FDFT1 which leads to decreased AKT/mTOR/HIF1a signalling and glycolysis reduction in colorectal cancer.
format	article
author	Mei-lin Weng Wan-kun Chen Xiang-yuan Chen Hong Lu Zhi-rong Sun Qi Yu Peng-fei Sun Ya-jun Xu Min-min Zhu Nan Jiang Jin Zhang Jian-ping Zhang Yuan-lin Song Duan Ma Xiao-ping Zhang Chang-hong Miao
author_facet	Mei-lin Weng Wan-kun Chen Xiang-yuan Chen Hong Lu Zhi-rong Sun Qi Yu Peng-fei Sun Ya-jun Xu Min-min Zhu Nan Jiang Jin Zhang Jian-ping Zhang Yuan-lin Song Duan Ma Xiao-ping Zhang Chang-hong Miao
author_sort	Mei-lin Weng
title	Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression
title_short	Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression
title_full	Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression
title_fullStr	Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression
title_full_unstemmed	Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression
title_sort	fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the fdft1-mediated akt/mtor/hif1α pathway suppression
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/292783a4478044e7aa00b20a1e94ff4e
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Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

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