Brain intraventricular injection of amyloid-β in zebrafish embryo impairs cognition and increases tau phosphorylation, effects reversed by lithium.

Brain intraventricular injection of amyloid-β in zebrafish embryo impairs cognition and increases tau phosphorylation, effects reversed by lithium.

Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no effective treatment and commonly diagnosed only on late stages. Amyloid-β (Aβ) accumulation and exacerbated tau phosphorylation are molecular hallmarks of AD implicated in cognitive deficits and synaptic and neuronal l...

Full description

Saved in:
Bibliographic Details
Main Authors: Laura Roesler Nery, Natalia Silva Eltz, Cristiana Hackman, Raphaela Fonseca, Stefani Altenhofen, Heydi Noriega Guerra, Vanessa Morais Freitas, Carla Denise Bonan, Monica Ryff Moreira Roca Vianna
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/2937cbe091024d56a6e05c6625d6754b
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items