HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death

HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death

Abstract The local anesthetic lidocaine induces cell death by altering reactive oxygen species (ROS) generation and mitochondrial electron transport chain function. Because hypoxia-inducible factor 1 (HIF-1) is involved in determining oxygen metabolism and mitochondria function, we investigated the...

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Main Authors: Akihisa Okamoto, Chisato Sumi, Hiromasa Tanaka, Munenori Kusunoki, Teppei Iwai, Kenichiro Nishi, Yoshiyuki Matsuo, Hiroshi Harada, Keizo Takenaga, Hidemasa Bono, Kiichi Hirota
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/294620230aa444ba9ef9c38cbfc88f43
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