Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells

T follicular regulatory cells control the magnitude of the germinal centre response. Here the authors show that these cells display specificity to self as well as foreign antigens, and can arise from Foxp3-negative precursors at early stages of immunization in a PD-L1 dependent manner.

Guardado en:

Detalles Bibliográficos
Autores principales:	Meryem Aloulou, Edward J. Carr, Mylène Gador, Alexandre Bignon, Roland S. Liblau, Nicolas Fazilleau, Michelle A. Linterman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/295284e73c8a4c66a06393b19e2b2e67
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:295284e73c8a4c66a06393b19e2b2e67
record_format	dspace
spelling	oai:doaj.org-article:295284e73c8a4c66a06393b19e2b2e672021-12-02T16:49:26ZFollicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells10.1038/ncomms105792041-1723https://doaj.org/article/295284e73c8a4c66a06393b19e2b2e672016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10579https://doaj.org/toc/2041-1723T follicular regulatory cells control the magnitude of the germinal centre response. Here the authors show that these cells display specificity to self as well as foreign antigens, and can arise from Foxp3-negative precursors at early stages of immunization in a PD-L1 dependent manner.Meryem AloulouEdward J. CarrMylène GadorAlexandre BignonRoland S. LiblauNicolas FazilleauMichelle A. LintermanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meryem Aloulou Edward J. Carr Mylène Gador Alexandre Bignon Roland S. Liblau Nicolas Fazilleau Michelle A. Linterman Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells
description	T follicular regulatory cells control the magnitude of the germinal centre response. Here the authors show that these cells display specificity to self as well as foreign antigens, and can arise from Foxp3-negative precursors at early stages of immunization in a PD-L1 dependent manner.
format	article
author	Meryem Aloulou Edward J. Carr Mylène Gador Alexandre Bignon Roland S. Liblau Nicolas Fazilleau Michelle A. Linterman
author_facet	Meryem Aloulou Edward J. Carr Mylène Gador Alexandre Bignon Roland S. Liblau Nicolas Fazilleau Michelle A. Linterman
author_sort	Meryem Aloulou
title	Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells
title_short	Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells
title_full	Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells
title_fullStr	Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells
title_full_unstemmed	Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells
title_sort	follicular regulatory t cells can be specific for the immunizing antigen and derive from naive t cells
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/295284e73c8a4c66a06393b19e2b2e67
work_keys_str_mv	AT meryemaloulou follicularregulatorytcellscanbespecificfortheimmunizingantigenandderivefromnaivetcells AT edwardjcarr follicularregulatorytcellscanbespecificfortheimmunizingantigenandderivefromnaivetcells AT mylenegador follicularregulatorytcellscanbespecificfortheimmunizingantigenandderivefromnaivetcells AT alexandrebignon follicularregulatorytcellscanbespecificfortheimmunizingantigenandderivefromnaivetcells AT rolandsliblau follicularregulatorytcellscanbespecificfortheimmunizingantigenandderivefromnaivetcells AT nicolasfazilleau follicularregulatorytcellscanbespecificfortheimmunizingantigenandderivefromnaivetcells AT michellealinterman follicularregulatorytcellscanbespecificfortheimmunizingantigenandderivefromnaivetcells
_version_	1718383324845572096

Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells

Ejemplares similares