Voltage-dependent modulation of cardiac ryanodine receptors (RyR2) by protamine.
It has been reported that protamine (>10 microg/ml) blocks single skeletal RyR1 channels and inhibits RyR1-mediated Ca2+ release from sarcoplasmic reticulum microsomes. We extended these studies to cardiac RyR2 reconstituted into planar lipid bilayers. We found that protamine (0.02-20 microg/ml)...
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Autores principales: | , |
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Formato: | article |
Lenguaje: | EN |
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Public Library of Science (PLoS)
2009
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Acceso en línea: | https://doaj.org/article/29734ad6b6524de9986ce53286e30318 |
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