Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway

Studying trisomic cell lines derived from RPE1 and HCT116 cells, Krivega et al find that autophagy is induced independently of mTORC1 in these cells. Rather, they observe that nuclear accumulation of TFEB and IRF3 and activation of the inflammatory response and autophagy in trisomic cells is depende...

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Autores principales:	Maria Krivega, Clara M. Stiefel, Sahar Karbassi, Line L. Andersen, Narendra K. Chunduri, Neysan Donnelly, Andreas Pichlmair, Zuzana Storchová
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2979d06198234571b4d7edada60a039a
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spelling	oai:doaj.org-article:2979d06198234571b4d7edada60a039a2021-12-02T16:10:32ZGenotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway10.1038/s42003-021-02278-92399-3642https://doaj.org/article/2979d06198234571b4d7edada60a039a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02278-9https://doaj.org/toc/2399-3642Studying trisomic cell lines derived from RPE1 and HCT116 cells, Krivega et al find that autophagy is induced independently of mTORC1 in these cells. Rather, they observe that nuclear accumulation of TFEB and IRF3 and activation of the inflammatory response and autophagy in trisomic cells is dependent on the cGAS-STING pathway.Maria KrivegaClara M. StiefelSahar KarbassiLine L. AndersenNarendra K. ChunduriNeysan DonnellyAndreas PichlmairZuzana StorchováNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Maria Krivega Clara M. Stiefel Sahar Karbassi Line L. Andersen Narendra K. Chunduri Neysan Donnelly Andreas Pichlmair Zuzana Storchová Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway
description	Studying trisomic cell lines derived from RPE1 and HCT116 cells, Krivega et al find that autophagy is induced independently of mTORC1 in these cells. Rather, they observe that nuclear accumulation of TFEB and IRF3 and activation of the inflammatory response and autophagy in trisomic cells is dependent on the cGAS-STING pathway.
format	article
author	Maria Krivega Clara M. Stiefel Sahar Karbassi Line L. Andersen Narendra K. Chunduri Neysan Donnelly Andreas Pichlmair Zuzana Storchová
author_facet	Maria Krivega Clara M. Stiefel Sahar Karbassi Line L. Andersen Narendra K. Chunduri Neysan Donnelly Andreas Pichlmair Zuzana Storchová
author_sort	Maria Krivega
title	Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway
title_short	Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway
title_full	Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway
title_fullStr	Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway
title_full_unstemmed	Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway
title_sort	genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cgas-sting pathway
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2979d06198234571b4d7edada60a039a
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Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway

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