Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features

Sirtuins are NAD+-dependent protein lysine deacylases that act as metabolic regulators and are linked to aging-related diseases. Here the authors present the Sirt4 crystal structure and show that the enzyme has dehydroxymethylglutarylation activity and is regulated by NADH.

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Autores principales:	Martin Pannek, Zeljko Simic, Matthew Fuszard, Marat Meleshin, Dante Rotili, Antonello Mai, Mike Schutkowski, Clemens Steegborn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/298bfa987a7f426aaac1db46f2257c2e
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spelling	oai:doaj.org-article:298bfa987a7f426aaac1db46f2257c2e2021-12-02T14:40:33ZCrystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features10.1038/s41467-017-01701-22041-1723https://doaj.org/article/298bfa987a7f426aaac1db46f2257c2e2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01701-2https://doaj.org/toc/2041-1723Sirtuins are NAD+-dependent protein lysine deacylases that act as metabolic regulators and are linked to aging-related diseases. Here the authors present the Sirt4 crystal structure and show that the enzyme has dehydroxymethylglutarylation activity and is regulated by NADH.Martin PannekZeljko SimicMatthew FuszardMarat MeleshinDante RotiliAntonello MaiMike SchutkowskiClemens SteegbornNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Pannek Zeljko Simic Matthew Fuszard Marat Meleshin Dante Rotili Antonello Mai Mike Schutkowski Clemens Steegborn Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features
description	Sirtuins are NAD+-dependent protein lysine deacylases that act as metabolic regulators and are linked to aging-related diseases. Here the authors present the Sirt4 crystal structure and show that the enzyme has dehydroxymethylglutarylation activity and is regulated by NADH.
format	article
author	Martin Pannek Zeljko Simic Matthew Fuszard Marat Meleshin Dante Rotili Antonello Mai Mike Schutkowski Clemens Steegborn
author_facet	Martin Pannek Zeljko Simic Matthew Fuszard Marat Meleshin Dante Rotili Antonello Mai Mike Schutkowski Clemens Steegborn
author_sort	Martin Pannek
title	Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features
title_short	Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features
title_full	Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features
title_fullStr	Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features
title_full_unstemmed	Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features
title_sort	crystal structures of the mitochondrial deacylase sirtuin 4 reveal isoform-specific acyl recognition and regulation features
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/298bfa987a7f426aaac1db46f2257c2e
work_keys_str_mv	AT martinpannek crystalstructuresofthemitochondrialdeacylasesirtuin4revealisoformspecificacylrecognitionandregulationfeatures AT zeljkosimic crystalstructuresofthemitochondrialdeacylasesirtuin4revealisoformspecificacylrecognitionandregulationfeatures AT matthewfuszard crystalstructuresofthemitochondrialdeacylasesirtuin4revealisoformspecificacylrecognitionandregulationfeatures AT maratmeleshin crystalstructuresofthemitochondrialdeacylasesirtuin4revealisoformspecificacylrecognitionandregulationfeatures AT danterotili crystalstructuresofthemitochondrialdeacylasesirtuin4revealisoformspecificacylrecognitionandregulationfeatures AT antonellomai crystalstructuresofthemitochondrialdeacylasesirtuin4revealisoformspecificacylrecognitionandregulationfeatures AT mikeschutkowski crystalstructuresofthemitochondrialdeacylasesirtuin4revealisoformspecificacylrecognitionandregulationfeatures AT clemenssteegborn crystalstructuresofthemitochondrialdeacylasesirtuin4revealisoformspecificacylrecognitionandregulationfeatures
_version_	1718390224055173120

Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features

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