Mechanism of partial agonism in AMPA-type glutamate receptors

Partial agonists weakly activate receptors even when occupying all available binding sites. Here the authors show that partial agonists of the AMPA receptor drive the adoption of multiple inactive forms, accounting for their limited efficacy.

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Autores principales: Hector Salazar, Clarissa Eibl, Miriam Chebli, Andrew Plested
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Q
Acceso en línea:https://doaj.org/article/299882cd5dc14ccfb46ea49f3ccbb9ae
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