Mechanism of partial agonism in AMPA-type glutamate receptors

Partial agonists weakly activate receptors even when occupying all available binding sites. Here the authors show that partial agonists of the AMPA receptor drive the adoption of multiple inactive forms, accounting for their limited efficacy.

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Autores principales:	Hector Salazar, Clarissa Eibl, Miriam Chebli, Andrew Plested
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/299882cd5dc14ccfb46ea49f3ccbb9ae
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spelling	oai:doaj.org-article:299882cd5dc14ccfb46ea49f3ccbb9ae2021-12-02T14:42:10ZMechanism of partial agonism in AMPA-type glutamate receptors10.1038/ncomms143272041-1723https://doaj.org/article/299882cd5dc14ccfb46ea49f3ccbb9ae2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14327https://doaj.org/toc/2041-1723Partial agonists weakly activate receptors even when occupying all available binding sites. Here the authors show that partial agonists of the AMPA receptor drive the adoption of multiple inactive forms, accounting for their limited efficacy.Hector SalazarClarissa EiblMiriam ChebliAndrew PlestedNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hector Salazar Clarissa Eibl Miriam Chebli Andrew Plested Mechanism of partial agonism in AMPA-type glutamate receptors
description	Partial agonists weakly activate receptors even when occupying all available binding sites. Here the authors show that partial agonists of the AMPA receptor drive the adoption of multiple inactive forms, accounting for their limited efficacy.
format	article
author	Hector Salazar Clarissa Eibl Miriam Chebli Andrew Plested
author_facet	Hector Salazar Clarissa Eibl Miriam Chebli Andrew Plested
author_sort	Hector Salazar
title	Mechanism of partial agonism in AMPA-type glutamate receptors
title_short	Mechanism of partial agonism in AMPA-type glutamate receptors
title_full	Mechanism of partial agonism in AMPA-type glutamate receptors
title_fullStr	Mechanism of partial agonism in AMPA-type glutamate receptors
title_full_unstemmed	Mechanism of partial agonism in AMPA-type glutamate receptors
title_sort	mechanism of partial agonism in ampa-type glutamate receptors
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/299882cd5dc14ccfb46ea49f3ccbb9ae
work_keys_str_mv	AT hectorsalazar mechanismofpartialagonisminampatypeglutamatereceptors AT clarissaeibl mechanismofpartialagonisminampatypeglutamatereceptors AT miriamchebli mechanismofpartialagonisminampatypeglutamatereceptors AT andrewplested mechanismofpartialagonisminampatypeglutamatereceptors
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Mechanism of partial agonism in AMPA-type glutamate receptors

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