Humanising the mouse genome piece by piece

Generation of transgenic mice has become routine in studying gene function and disease mechanisms, but often this is not enough to fully understand human biology. Here, the authors review the current state of the art of targeted genomic humanisation strategies and their advantages over classic appro...

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Autores principales:	Fei Zhu, Remya R. Nair, Elizabeth M. C. Fisher, Thomas J. Cunningham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/29c79726f62740aba33706a6284e124b
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spelling	oai:doaj.org-article:29c79726f62740aba33706a6284e124b2021-12-02T17:31:53ZHumanising the mouse genome piece by piece10.1038/s41467-019-09716-72041-1723https://doaj.org/article/29c79726f62740aba33706a6284e124b2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09716-7https://doaj.org/toc/2041-1723Generation of transgenic mice has become routine in studying gene function and disease mechanisms, but often this is not enough to fully understand human biology. Here, the authors review the current state of the art of targeted genomic humanisation strategies and their advantages over classic approaches.Fei ZhuRemya R. NairElizabeth M. C. FisherThomas J. CunninghamNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fei Zhu Remya R. Nair Elizabeth M. C. Fisher Thomas J. Cunningham Humanising the mouse genome piece by piece
description	Generation of transgenic mice has become routine in studying gene function and disease mechanisms, but often this is not enough to fully understand human biology. Here, the authors review the current state of the art of targeted genomic humanisation strategies and their advantages over classic approaches.
format	article
author	Fei Zhu Remya R. Nair Elizabeth M. C. Fisher Thomas J. Cunningham
author_facet	Fei Zhu Remya R. Nair Elizabeth M. C. Fisher Thomas J. Cunningham
author_sort	Fei Zhu
title	Humanising the mouse genome piece by piece
title_short	Humanising the mouse genome piece by piece
title_full	Humanising the mouse genome piece by piece
title_fullStr	Humanising the mouse genome piece by piece
title_full_unstemmed	Humanising the mouse genome piece by piece
title_sort	humanising the mouse genome piece by piece
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/29c79726f62740aba33706a6284e124b
work_keys_str_mv	AT feizhu humanisingthemousegenomepiecebypiece AT remyarnair humanisingthemousegenomepiecebypiece AT elizabethmcfisher humanisingthemousegenomepiecebypiece AT thomasjcunningham humanisingthemousegenomepiecebypiece
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Humanising the mouse genome piece by piece

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