M Protein and Hyaluronic Acid Capsule Are Essential for <italic toggle="yes">In Vivo</italic> Selection of <italic toggle="yes">covRS</italic> Mutations Characteristic of Invasive Serotype M1T1 Group A <italic toggle="yes">Streptococcus</italic>

M Protein and Hyaluronic Acid Capsule Are Essential for <italic toggle="yes">In Vivo</italic> Selection of <italic toggle="yes">covRS</italic> Mutations Characteristic of Invasive Serotype M1T1 Group A <italic toggle="yes">Streptococcus</italic>

ABSTRACT The initiation of hyperinvasive disease in group A Streptococcus (GAS) serotype M1T1 occurs by mutation within the covRS two-component regulon (named covRS for control of virulence regulatory sensor kinase), which promotes resistance to neutrophil-mediated killing through the upregulation o...

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Autores principales: Jason N. Cole, Morgan A. Pence, Maren von Köckritz-Blickwede, Andrew Hollands, Richard L. Gallo, Mark J. Walker, Victor Nizet
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2010
Materias:
Microbiology
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Acceso en línea:https://doaj.org/article/29d2718b948441769760790a55214328
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