Metformin-induced suppression of IFN-α via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes

Metformin-induced suppression of IFN-α via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes

Abstract Diabetes mellitus (DM) patients are at an increased risk of complications following influenza-virus infection, seasonal vaccination (SV) is recommended. However, SV with trivalent influenza vaccine (TIV) can induce antibody and type-I interferon (IFN) responses, and the effect of anti-DM tr...

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Main Authors: Wipawee Saenwongsa, Arnone Nithichanon, Malinee Chittaganpitch, Kampaew Buayai, Chidchamai Kewcharoenwong, Boonyarat Thumrongwilainet, Patcharavadee Butta, Tanapat Palaga, Yoshimasa Takahashi, Manabu Ato, Ganjana Lertmemongkolchai
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/29f147898f844010845b81693da79602
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https://doaj.org/article/29f147898f844010845b81693da79602

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