Metformin-induced suppression of IFN-α via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes
Abstract Diabetes mellitus (DM) patients are at an increased risk of complications following influenza-virus infection, seasonal vaccination (SV) is recommended. However, SV with trivalent influenza vaccine (TIV) can induce antibody and type-I interferon (IFN) responses, and the effect of anti-DM tr...
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Autores principales: | Wipawee Saenwongsa, Arnone Nithichanon, Malinee Chittaganpitch, Kampaew Buayai, Chidchamai Kewcharoenwong, Boonyarat Thumrongwilainet, Patcharavadee Butta, Tanapat Palaga, Yoshimasa Takahashi, Manabu Ato, Ganjana Lertmemongkolchai |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
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Materias: | |
Acceso en línea: | https://doaj.org/article/29f147898f844010845b81693da79602 |
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