Importance of the 1+7 configuration of ribonucleoprotein complexes for influenza A virus genome packaging

Influenza A virus (IAV) packages its eight genomic RNA segments in a specific “1+7” pattern. Here, the authors generate IAV that lack one RNA segment and show that ribosomal RNA is packaged in place of the eighth segment, suggesting that the 1+7 pattern is important for particle production.

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Auteurs principaux: Takeshi Noda, Shin Murakami, Sumiho Nakatsu, Hirotaka Imai, Yukiko Muramoto, Keiko Shindo, Hiroshi Sagara, Yoshihiro Kawaoka
Format: article
Langue:EN
Publié: Nature Portfolio 2018
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Accès en ligne:https://doaj.org/article/2a145101eed44b61997b802d91bc2974
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