Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis

Mutations in VHL have been linked to clear cell renal cancer, but the molecular mechanisms involved remain unclear. Here the authors generate a mouse model closely mimicking the human disease and show that VHL loss induces DNA replication stress that is rescued by the concomitant loss of PBRM1 permi...

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Autores principales:	Judit Espana-Agusti, Anne Warren, Su Kit Chew, David J. Adams, Athena Matakidou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a15b52553454c128bb092ae2e0904c7
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spelling	oai:doaj.org-article:2a15b52553454c128bb092ae2e0904c72021-12-02T14:41:18ZLoss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis10.1038/s41467-017-02245-12041-1723https://doaj.org/article/2a15b52553454c128bb092ae2e0904c72017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02245-1https://doaj.org/toc/2041-1723Mutations in VHL have been linked to clear cell renal cancer, but the molecular mechanisms involved remain unclear. Here the authors generate a mouse model closely mimicking the human disease and show that VHL loss induces DNA replication stress that is rescued by the concomitant loss of PBRM1 permitting transformation.Judit Espana-AgustiAnne WarrenSu Kit ChewDavid J. AdamsAthena MatakidouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Judit Espana-Agusti Anne Warren Su Kit Chew David J. Adams Athena Matakidou Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis
description	Mutations in VHL have been linked to clear cell renal cancer, but the molecular mechanisms involved remain unclear. Here the authors generate a mouse model closely mimicking the human disease and show that VHL loss induces DNA replication stress that is rescued by the concomitant loss of PBRM1 permitting transformation.
format	article
author	Judit Espana-Agusti Anne Warren Su Kit Chew David J. Adams Athena Matakidou
author_facet	Judit Espana-Agusti Anne Warren Su Kit Chew David J. Adams Athena Matakidou
author_sort	Judit Espana-Agusti
title	Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis
title_short	Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis
title_full	Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis
title_fullStr	Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis
title_full_unstemmed	Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis
title_sort	loss of pbrm1 rescues vhl dependent replication stress to promote renal carcinogenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2a15b52553454c128bb092ae2e0904c7
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Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis

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