WASP family proteins regulate the mobility of the B cell receptor during signaling activation

B cell receptors (BCR) capture antigen and initiate downstream antibody responses, but whether and how BCR signaling is regulated by BCR mobility is still unclear. Here the authors show, using single molecule imaging and machine learning analyses, that BCR and CD19 mobility is modulated by the actin...

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Autores principales:	Ivan Rey-Suarez, Brittany A. Wheatley, Peter Koo, Anshuman Bhanja, Zhou Shu, Simon Mochrie, Wenxia Song, Hari Shroff, Arpita Upadhyaya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a250cd833d54780bbb3012f5d131e7e
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spelling	oai:doaj.org-article:2a250cd833d54780bbb3012f5d131e7e2021-12-02T15:37:20ZWASP family proteins regulate the mobility of the B cell receptor during signaling activation10.1038/s41467-020-14335-82041-1723https://doaj.org/article/2a250cd833d54780bbb3012f5d131e7e2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14335-8https://doaj.org/toc/2041-1723B cell receptors (BCR) capture antigen and initiate downstream antibody responses, but whether and how BCR signaling is regulated by BCR mobility is still unclear. Here the authors show, using single molecule imaging and machine learning analyses, that BCR and CD19 mobility is modulated by the actin nucleation regulators Arp2/3 and N-WASP to control BCR signaling.Ivan Rey-SuarezBrittany A. WheatleyPeter KooAnshuman BhanjaZhou ShuSimon MochrieWenxia SongHari ShroffArpita UpadhyayaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ivan Rey-Suarez Brittany A. Wheatley Peter Koo Anshuman Bhanja Zhou Shu Simon Mochrie Wenxia Song Hari Shroff Arpita Upadhyaya WASP family proteins regulate the mobility of the B cell receptor during signaling activation
description	B cell receptors (BCR) capture antigen and initiate downstream antibody responses, but whether and how BCR signaling is regulated by BCR mobility is still unclear. Here the authors show, using single molecule imaging and machine learning analyses, that BCR and CD19 mobility is modulated by the actin nucleation regulators Arp2/3 and N-WASP to control BCR signaling.
format	article
author	Ivan Rey-Suarez Brittany A. Wheatley Peter Koo Anshuman Bhanja Zhou Shu Simon Mochrie Wenxia Song Hari Shroff Arpita Upadhyaya
author_facet	Ivan Rey-Suarez Brittany A. Wheatley Peter Koo Anshuman Bhanja Zhou Shu Simon Mochrie Wenxia Song Hari Shroff Arpita Upadhyaya
author_sort	Ivan Rey-Suarez
title	WASP family proteins regulate the mobility of the B cell receptor during signaling activation
title_short	WASP family proteins regulate the mobility of the B cell receptor during signaling activation
title_full	WASP family proteins regulate the mobility of the B cell receptor during signaling activation
title_fullStr	WASP family proteins regulate the mobility of the B cell receptor during signaling activation
title_full_unstemmed	WASP family proteins regulate the mobility of the B cell receptor during signaling activation
title_sort	wasp family proteins regulate the mobility of the b cell receptor during signaling activation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2a250cd833d54780bbb3012f5d131e7e
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WASP family proteins regulate the mobility of the B cell receptor during signaling activation

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