Anthrax lethal factor as an immune target in humans and transgenic mice and the impact of HLA polymorphism on CD4+ T cell immunity.

Bacillus anthracis produces a binary toxin composed of protective antigen (PA) and one of two subunits, lethal factor (LF) or edema factor (EF). Most studies have concentrated on induction of toxin-specific antibodies as the correlate of protective immunity, in contrast to which understanding of cel...

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Bibliographic Details
Main Authors:	Stephanie Ascough, Rebecca J Ingram, Karen K Chu, Catherine J Reynolds, Julie A Musson, Mehmet Doganay, Gökhan Metan, Yusuf Ozkul, Les Baillie, Shiranee Sriskandan, Stephen J Moore, Theresa B Gallagher, Hugh Dyson, E Diane Williamson, John H Robinson, Bernard Maillere, Rosemary J Boyton, Daniel M Altmann
Format:	article
Language:	EN
Published:	Public Library of Science (PLoS) 2014
Subjects:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Online Access:	https://doaj.org/article/2a3497e4431447f1bf25d62970f3f8fb
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Anthrax lethal factor as an immune target in humans and transgenic mice and the impact of HLA polymorphism on CD4+ T cell immunity.

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