Stabilisation of half MCM ring by Cdt1 during DNA insertion

During pre-Replication Complex, eukaryotic cells load two MCMs into a head-to-head Double Hexamer around duplex DNA (DH). Here the authors preRC assembly assay with purified proteins to reveal insights into S. cerevisiae’s first steps that lead to the DH formation.

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Autores principales: Marina Guerrero-Puigdevall, Narcis Fernandez-Fuentes, Jordi Frigola
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2a3a272cd120490cb93389b9e9ed49dd
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