Global Spread of Mutant PfCRT and Its Pleiotropic Impact on <named-content content-type="genus-species">Plasmodium falciparum</named-content> Multidrug Resistance and Fitness

Global Spread of Mutant PfCRT and Its Pleiotropic Impact on <named-content content-type="genus-species">Plasmodium falciparum</named-content> Multidrug Resistance and Fitness

ABSTRACT The global spread of Plasmodium falciparum chloroquine resistance transporter (PfCRT) variant haplotypes earlier caused the widespread loss of chloroquine (CQ) efficacy. In Asia, novel PfCRT mutations that emerged on the Dd2 allelic background have recently been implicated in high-level res...

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Autores principales: Satish K. Dhingra, Stanislaw J. Gabryszewski, Jennifer L. Small-Saunders, Tomas Yeo, Philipp P. Henrich, Sachel Mok, David A. Fidock
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
Plasmodium falciparum
drug resistance evolution
fitness
malaria
pfcrt
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/2a3f85165c494c71b5a68c721206927b
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