The octadecaneuropeptide ODN protects astrocytes against hydrogen peroxide-induced apoptosis via a PKA/MAPK-dependent mechanism.

The octadecaneuropeptide ODN protects astrocytes against hydrogen peroxide-induced apoptosis via a PKA/MAPK-dependent mechanism.

Astrocytes synthesize and release endozepines, a family of regulatory peptides, including the octadecaneuropeptide (ODN) an endogenous ligand of both central-type benzodiazepine (CBR) and metabotropic receptors. We have recently shown that ODN exerts a protective effect against hydrogen peroxide (H(...

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Autores principales: Yosra Hamdi, Hadhemi Kaddour, David Vaudry, Seyma Bahdoudi, Salma Douiri, Jérôme Leprince, Helene Castel, Hubert Vaudry, Marie-Christine Tonon, Mohamed Amri, Olfa Masmoudi-Kouki
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/2a4eb8a96daa40d2bc4e22678176269a
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https://doaj.org/article/2a4eb8a96daa40d2bc4e22678176269a

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