A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation

A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation

Development of a safe and efficacious vaccine for respiratory syncytial virus (RSV) has been challenging. Here the authors generate a live-attenuated RSV vaccine that shows increased thermostability and immunogenicity, and protects cotton rats from RSV challenge.

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Detalles Bibliográficos
Autores principales: Christopher C. Stobart, Christina A. Rostad, Zunlong Ke, Rebecca S. Dillard, Cheri M. Hampton, Joshua D. Strauss, Hong Yi, Anne L. Hotard, Jia Meng, Raymond J. Pickles, Kaori Sakamoto, Sujin Lee, Michael G. Currier, Syed M. Moin, Barney S. Graham, Marina S. Boukhvalova, Brian E. Gilbert, Jorge C. G. Blanco, Pedro A. Piedra, Elizabeth R. Wright, Martin L. Moore
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/2a61be93aec04ad3a0b22213856c0d55
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Descripción
Sumario:Development of a safe and efficacious vaccine for respiratory syncytial virus (RSV) has been challenging. Here the authors generate a live-attenuated RSV vaccine that shows increased thermostability and immunogenicity, and protects cotton rats from RSV challenge.

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