A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation

A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation

Development of a safe and efficacious vaccine for respiratory syncytial virus (RSV) has been challenging. Here the authors generate a live-attenuated RSV vaccine that shows increased thermostability and immunogenicity, and protects cotton rats from RSV challenge.

Guardado en:
Detalles Bibliográficos
Autores principales: Christopher C. Stobart, Christina A. Rostad, Zunlong Ke, Rebecca S. Dillard, Cheri M. Hampton, Joshua D. Strauss, Hong Yi, Anne L. Hotard, Jia Meng, Raymond J. Pickles, Kaori Sakamoto, Sujin Lee, Michael G. Currier, Syed M. Moin, Barney S. Graham, Marina S. Boukhvalova, Brian E. Gilbert, Jorge C. G. Blanco, Pedro A. Piedra, Elizabeth R. Wright, Martin L. Moore
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/2a61be93aec04ad3a0b22213856c0d55
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:2a61be93aec04ad3a0b22213856c0d55
record_format dspace
spelling oai:doaj.org-article:2a61be93aec04ad3a0b22213856c0d552021-12-02T16:49:42ZA live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation10.1038/ncomms139162041-1723https://doaj.org/article/2a61be93aec04ad3a0b22213856c0d552016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13916https://doaj.org/toc/2041-1723Development of a safe and efficacious vaccine for respiratory syncytial virus (RSV) has been challenging. Here the authors generate a live-attenuated RSV vaccine that shows increased thermostability and immunogenicity, and protects cotton rats from RSV challenge.Christopher C. StobartChristina A. RostadZunlong KeRebecca S. DillardCheri M. HamptonJoshua D. StraussHong YiAnne L. HotardJia MengRaymond J. PicklesKaori SakamotoSujin LeeMichael G. CurrierSyed M. MoinBarney S. GrahamMarina S. BoukhvalovaBrian E. GilbertJorge C. G. BlancoPedro A. PiedraElizabeth R. WrightMartin L. MooreNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Christopher C. Stobart
Christina A. Rostad
Zunlong Ke
Rebecca S. Dillard
Cheri M. Hampton
Joshua D. Strauss
Hong Yi
Anne L. Hotard
Jia Meng
Raymond J. Pickles
Kaori Sakamoto
Sujin Lee
Michael G. Currier
Syed M. Moin
Barney S. Graham
Marina S. Boukhvalova
Brian E. Gilbert
Jorge C. G. Blanco
Pedro A. Piedra
Elizabeth R. Wright
Martin L. Moore
A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation
description Development of a safe and efficacious vaccine for respiratory syncytial virus (RSV) has been challenging. Here the authors generate a live-attenuated RSV vaccine that shows increased thermostability and immunogenicity, and protects cotton rats from RSV challenge.
format article
author Christopher C. Stobart
Christina A. Rostad
Zunlong Ke
Rebecca S. Dillard
Cheri M. Hampton
Joshua D. Strauss
Hong Yi
Anne L. Hotard
Jia Meng
Raymond J. Pickles
Kaori Sakamoto
Sujin Lee
Michael G. Currier
Syed M. Moin
Barney S. Graham
Marina S. Boukhvalova
Brian E. Gilbert
Jorge C. G. Blanco
Pedro A. Piedra
Elizabeth R. Wright
Martin L. Moore
author_facet Christopher C. Stobart
Christina A. Rostad
Zunlong Ke
Rebecca S. Dillard
Cheri M. Hampton
Joshua D. Strauss
Hong Yi
Anne L. Hotard
Jia Meng
Raymond J. Pickles
Kaori Sakamoto
Sujin Lee
Michael G. Currier
Syed M. Moin
Barney S. Graham
Marina S. Boukhvalova
Brian E. Gilbert
Jorge C. G. Blanco
Pedro A. Piedra
Elizabeth R. Wright
Martin L. Moore
author_sort Christopher C. Stobart
title A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation
title_short A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation
title_full A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation
title_fullStr A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation
title_full_unstemmed A live RSV vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation
title_sort live rsv vaccine with engineered thermostability is immunogenic in cotton rats despite high attenuation
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/2a61be93aec04ad3a0b22213856c0d55
work_keys_str_mv AT christophercstobart aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT christinaarostad aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT zunlongke aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT rebeccasdillard aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT cherimhampton aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT joshuadstrauss aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT hongyi aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT annelhotard aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT jiameng aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT raymondjpickles aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT kaorisakamoto aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT sujinlee aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT michaelgcurrier aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT syedmmoin aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT barneysgraham aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT marinasboukhvalova aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT brianegilbert aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT jorgecgblanco aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT pedroapiedra aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT elizabethrwright aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT martinlmoore aliversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT christophercstobart liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT christinaarostad liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT zunlongke liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT rebeccasdillard liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT cherimhampton liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT joshuadstrauss liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT hongyi liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT annelhotard liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT jiameng liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT raymondjpickles liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT kaorisakamoto liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT sujinlee liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT michaelgcurrier liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT syedmmoin liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT barneysgraham liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT marinasboukhvalova liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT brianegilbert liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT jorgecgblanco liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT pedroapiedra liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT elizabethrwright liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
AT martinlmoore liversvvaccinewithengineeredthermostabilityisimmunogenicincottonratsdespitehighattenuation
_version_ 1718383204734337024

Ejemplares similares