Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer

G protein-coupled receptors (GPCRs), such as GABAB, can integrate extracellular signals via allosteric interactions within dimers and oligomers. Here authors use crosslinking and identify two transmembrane interfaces in GABAB which undergo a concerted rearrangement upon agonist activation.

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Detalles Bibliográficos
Autores principales:	Li Xue, Qian Sun, Han Zhao, Xavier Rovira, Siyu Gai, Qianwen He, Jean-Philippe Pin, Jianfeng Liu, Philippe Rondard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a62f546d82a4973a65a19204b56e900
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spelling	oai:doaj.org-article:2a62f546d82a4973a65a19204b56e9002021-12-02T15:35:17ZRearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer10.1038/s41467-019-10834-52041-1723https://doaj.org/article/2a62f546d82a4973a65a19204b56e9002019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10834-5https://doaj.org/toc/2041-1723G protein-coupled receptors (GPCRs), such as GABAB, can integrate extracellular signals via allosteric interactions within dimers and oligomers. Here authors use crosslinking and identify two transmembrane interfaces in GABAB which undergo a concerted rearrangement upon agonist activation.Li XueQian SunHan ZhaoXavier RoviraSiyu GaiQianwen HeJean-Philippe PinJianfeng LiuPhilippe RondardNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Li Xue Qian Sun Han Zhao Xavier Rovira Siyu Gai Qianwen He Jean-Philippe Pin Jianfeng Liu Philippe Rondard Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer
description	G protein-coupled receptors (GPCRs), such as GABAB, can integrate extracellular signals via allosteric interactions within dimers and oligomers. Here authors use crosslinking and identify two transmembrane interfaces in GABAB which undergo a concerted rearrangement upon agonist activation.
format	article
author	Li Xue Qian Sun Han Zhao Xavier Rovira Siyu Gai Qianwen He Jean-Philippe Pin Jianfeng Liu Philippe Rondard
author_facet	Li Xue Qian Sun Han Zhao Xavier Rovira Siyu Gai Qianwen He Jean-Philippe Pin Jianfeng Liu Philippe Rondard
author_sort	Li Xue
title	Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer
title_short	Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer
title_full	Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer
title_fullStr	Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer
title_full_unstemmed	Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer
title_sort	rearrangement of the transmembrane domain interfaces associated with the activation of a gpcr hetero-oligomer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2a62f546d82a4973a65a19204b56e900
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Rearrangement of the transmembrane domain interfaces associated with the activation of a GPCR hetero-oligomer

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