Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation

Accumulation of advanced glycation end products such as carboxymethyllysine (CML) has been associated with aging but their molecular roles are largely unclear. Here, the authors use proteomics to identify CML sites and show that CML formation affects protein homeostasis and cell proliferation.

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Bibliographic Details
Main Authors: Simone Di Sanzo, Katrin Spengler, Anja Leheis, Joanna M. Kirkpatrick, Theresa L. Rändler, Tim Baldensperger, Therese Dau, Christian Henning, Luca Parca, Christian Marx, Zhao-Qi Wang, Marcus A. Glomb, Alessandro Ori, Regine Heller
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/2a95d56d607f461daa73332371e24e27
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