Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation

Accumulation of advanced glycation end products such as carboxymethyllysine (CML) has been associated with aging but their molecular roles are largely unclear. Here, the authors use proteomics to identify CML sites and show that CML formation affects protein homeostasis and cell proliferation.

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Autores principales:	Simone Di Sanzo, Katrin Spengler, Anja Leheis, Joanna M. Kirkpatrick, Theresa L. Rändler, Tim Baldensperger, Therese Dau, Christian Henning, Luca Parca, Christian Marx, Zhao-Qi Wang, Marcus A. Glomb, Alessandro Ori, Regine Heller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2a95d56d607f461daa73332371e24e27
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spelling	oai:doaj.org-article:2a95d56d607f461daa73332371e24e272021-11-21T12:36:10ZMapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation10.1038/s41467-021-26982-62041-1723https://doaj.org/article/2a95d56d607f461daa73332371e24e272021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26982-6https://doaj.org/toc/2041-1723Accumulation of advanced glycation end products such as carboxymethyllysine (CML) has been associated with aging but their molecular roles are largely unclear. Here, the authors use proteomics to identify CML sites and show that CML formation affects protein homeostasis and cell proliferation.Simone Di SanzoKatrin SpenglerAnja LeheisJoanna M. KirkpatrickTheresa L. RändlerTim BaldenspergerTherese DauChristian HenningLuca ParcaChristian MarxZhao-Qi WangMarcus A. GlombAlessandro OriRegine HellerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simone Di Sanzo Katrin Spengler Anja Leheis Joanna M. Kirkpatrick Theresa L. Rändler Tim Baldensperger Therese Dau Christian Henning Luca Parca Christian Marx Zhao-Qi Wang Marcus A. Glomb Alessandro Ori Regine Heller Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation
description	Accumulation of advanced glycation end products such as carboxymethyllysine (CML) has been associated with aging but their molecular roles are largely unclear. Here, the authors use proteomics to identify CML sites and show that CML formation affects protein homeostasis and cell proliferation.
format	article
author	Simone Di Sanzo Katrin Spengler Anja Leheis Joanna M. Kirkpatrick Theresa L. Rändler Tim Baldensperger Therese Dau Christian Henning Luca Parca Christian Marx Zhao-Qi Wang Marcus A. Glomb Alessandro Ori Regine Heller
author_facet	Simone Di Sanzo Katrin Spengler Anja Leheis Joanna M. Kirkpatrick Theresa L. Rändler Tim Baldensperger Therese Dau Christian Henning Luca Parca Christian Marx Zhao-Qi Wang Marcus A. Glomb Alessandro Ori Regine Heller
author_sort	Simone Di Sanzo
title	Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation
title_short	Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation
title_full	Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation
title_fullStr	Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation
title_full_unstemmed	Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation
title_sort	mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2a95d56d607f461daa73332371e24e27
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Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation

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