Trypanosoma cruzi response to sterol biosynthesis inhibitors: morphophysiological alterations leading to cell death.
The protozoan parasite Trypanosoma cruzi displays similarities to fungi in terms of its sterol lipid biosynthesis, as ergosterol and other 24-alkylated sterols are its principal endogenous sterols. The sterol pathway is thus a potential drug target for the treatment of Chagas disease. We describe he...
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| Auteurs principaux: | , , , |
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| Format: | article |
| Langue: | EN |
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Public Library of Science (PLoS)
2013
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| Accès en ligne: | https://doaj.org/article/2b01eedac0dc4244a50b6389ca1fe82f |
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