Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions

SARS-CoV-2, the causative agent of COVID-19, has caused more than 60 million cases worldwide with almost 1.5 million deaths as of November 2020. Repurposing existing drugs is the most rapid path to clinical intervention for emerging diseases.

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Autores principales:	Christopher J. Day, Benjamin Bailly, Patrice Guillon, Larissa Dirr, Freda E.-C. Jen, Belinda L. Spillings, Johnson Mak, Mark von Itzstein, Thomas Haselhorst, Michael P. Jennings
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2b06afb56d02402cb0d88feb912f1af0
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spelling	oai:doaj.org-article:2b06afb56d02402cb0d88feb912f1af02021-11-03T18:56:10ZMultidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions2150-751110.1128/mBio.03681-20https://doaj.org/article/2b06afb56d02402cb0d88feb912f1af02021-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.03681-20https://doaj.org/toc/2150-7511 SARS-CoV-2, the causative agent of COVID-19, has caused more than 60 million cases worldwide with almost 1.5 million deaths as of November 2020. Repurposing existing drugs is the most rapid path to clinical intervention for emerging diseases.Christopher J. DayBenjamin BaillyPatrice GuillonLarissa DirrFreda E.-C. JenBelinda L. SpillingsJohnson MakMark von ItzsteinThomas HaselhorstMichael P. JenningsAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Christopher J. Day Benjamin Bailly Patrice Guillon Larissa Dirr Freda E.-C. Jen Belinda L. Spillings Johnson Mak Mark von Itzstein Thomas Haselhorst Michael P. Jennings Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions
description	SARS-CoV-2, the causative agent of COVID-19, has caused more than 60 million cases worldwide with almost 1.5 million deaths as of November 2020. Repurposing existing drugs is the most rapid path to clinical intervention for emerging diseases.
format	article
author	Christopher J. Day Benjamin Bailly Patrice Guillon Larissa Dirr Freda E.-C. Jen Belinda L. Spillings Johnson Mak Mark von Itzstein Thomas Haselhorst Michael P. Jennings
author_facet	Christopher J. Day Benjamin Bailly Patrice Guillon Larissa Dirr Freda E.-C. Jen Belinda L. Spillings Johnson Mak Mark von Itzstein Thomas Haselhorst Michael P. Jennings
author_sort	Christopher J. Day
title	Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions
title_short	Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions
title_full	Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions
title_fullStr	Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions
title_full_unstemmed	Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions
title_sort	multidisciplinary approaches identify compounds that bind to human ace2 or sars-cov-2 spike protein as candidates to block sars-cov-2–ace2 receptor interactions
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/2b06afb56d02402cb0d88feb912f1af0
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Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2–ACE2 Receptor Interactions

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