Single-particle mass analysis of intact ribosomes by mass photometry and Orbitrap-based charge detection mass spectrometry

Summary: Standard methods for mass analysis measure ensembles of thousand to millions of molecules. This approach enables analysis of monodisperse recombinant proteins, whereas some heterogeneous protein assemblies pose a significant challenge, whereby co-occurring stoichiometries, sub-complexes, an...

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Bibliographic Details
Main Authors: Szu-Hsueh Lai, Sem Tamara, Albert J.R. Heck
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
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Online Access:https://doaj.org/article/2b24d1a3985d4ec0966e7f67b9c53aee
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