TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species.

TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species.

Simian immunodeficiency viruses of sooty mangabeys (SIVsm) are the source of multiple, successful cross-species transmissions, having given rise to HIV-2 in humans, SIVmac in rhesus macaques, and SIVstm in stump-tailed macaques. Cellular assays and phylogenetic comparisons indirectly support a role...

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Autores principales: Andrea Kirmaier, Fan Wu, Ruchi M Newman, Laura R Hall, Jennifer S Morgan, Shelby O'Connor, Preston A Marx, Mareike Meythaler, Simoy Goldstein, Alicia Buckler-White, Amitinder Kaur, Vanessa M Hirsch, Welkin E Johnson
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/2b323af8d509493d92d86801abf66822
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