ONC201/TIC10 Is Empowered by 2-Deoxyglucose and Causes Metabolic Reprogramming in Medulloblastoma Cells in Vitro Independent of C-Myc Expression

ONC201/TIC10 Is Empowered by 2-Deoxyglucose and Causes Metabolic Reprogramming in Medulloblastoma Cells in Vitro Independent of C-Myc Expression

The purpose of this study was to examine whether the imipridone ONC201/TIC10 affects the metabolic and proliferative activity of medulloblastoma cells in vitro. Preclinical drug testing including extracellular flux analyses (agilent seahorse), MTT assays and Western blot analyses were performed in h...

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Autores principales: Annika Dwucet, Maximilian Pruss, Qiyu Cao, Mine Tanriover, Varun V. Prabhu, Joshua E. Allen, Aurelia Peraud, Mike-Andrew Westhoff, Markus D. Siegelin, Christian Rainer Wirtz, Georg Karpel-Massler
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
medulloblastoma
ONC201/TIC10
2-Deoxyglucose
seahorse
metabolism
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/2b45188c50c34313bc4b235cbf25243c
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https://doaj.org/article/2b45188c50c34313bc4b235cbf25243c

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