ONC201/TIC10 Is Empowered by 2-Deoxyglucose and Causes Metabolic Reprogramming in Medulloblastoma Cells in Vitro Independent of C-Myc Expression
The purpose of this study was to examine whether the imipridone ONC201/TIC10 affects the metabolic and proliferative activity of medulloblastoma cells in vitro. Preclinical drug testing including extracellular flux analyses (agilent seahorse), MTT assays and Western blot analyses were performed in h...
Guardado en:
Autores principales: | Annika Dwucet, Maximilian Pruss, Qiyu Cao, Mine Tanriover, Varun V. Prabhu, Joshua E. Allen, Aurelia Peraud, Mike-Andrew Westhoff, Markus D. Siegelin, Christian Rainer Wirtz, Georg Karpel-Massler |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/2b45188c50c34313bc4b235cbf25243c |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Co-delivery nanocarriers targeting folate receptor and encapsulating 2-deoxyglucose and α-tocopheryl succinate enhance anti-tumor effect in vivo
por: Lei X, et al.
Publicado: (2017) -
The impact of magnetic resonance imaging spectroscopy parameters on differentiating between paediatric medulloblastoma and ependymoma
por: Nguyen Minh Duc
Publicado: (2021) -
Immunotherapy in Medulloblastoma: Current State of Research, Challenges, and Future Perspectives
por: Marije J. Voskamp, et al.
Publicado: (2021) -
UDP-4-Keto-6-Deoxyglucose, a Transient Antifungal Metabolite, Weakens the Fungal Cell Wall Partly by Inhibition of UDP-Galactopyranose Mutase
por: Liang Ma, et al.
Publicado: (2017) -
Identification of an Immunogenic Medulloblastoma-Specific Fusion Involving <i>EPC2</i> and <i>GULP1</i>
por: Claudia Paret, et al.
Publicado: (2021)