Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway
Intestinal aging is associated with declines in structure and absorption of nutrients. Here, the authors show that aging related intestinal decline is mediated by activation of the mTORC1-p38MAPK-p53 pathway in intestinal stem cells and can be ameliorated by abrogating mTORC1 or p38MAPK activity.
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Nature Portfolio
2020
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oai:doaj.org-article:2b693f1be87a4d81b68d6deb696ecba72021-12-02T14:41:12ZGut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway10.1038/s41467-019-13911-x2041-1723https://doaj.org/article/2b693f1be87a4d81b68d6deb696ecba72020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13911-xhttps://doaj.org/toc/2041-1723Intestinal aging is associated with declines in structure and absorption of nutrients. Here, the authors show that aging related intestinal decline is mediated by activation of the mTORC1-p38MAPK-p53 pathway in intestinal stem cells and can be ameliorated by abrogating mTORC1 or p38MAPK activity.Dan HeHongguang WuJinnan XiangXinsen RuanPeike PengYuanyuan RuanYe-Guang ChenYibin WangQiang YuHongbing ZhangSamy L. HabibRonald A. De PinhoHuijuan LiuBaojie LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Dan He Hongguang Wu Jinnan Xiang Xinsen Ruan Peike Peng Yuanyuan Ruan Ye-Guang Chen Yibin Wang Qiang Yu Hongbing Zhang Samy L. Habib Ronald A. De Pinho Huijuan Liu Baojie Li Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway |
| description |
Intestinal aging is associated with declines in structure and absorption of nutrients. Here, the authors show that aging related intestinal decline is mediated by activation of the mTORC1-p38MAPK-p53 pathway in intestinal stem cells and can be ameliorated by abrogating mTORC1 or p38MAPK activity. |
| format |
article |
| author |
Dan He Hongguang Wu Jinnan Xiang Xinsen Ruan Peike Peng Yuanyuan Ruan Ye-Guang Chen Yibin Wang Qiang Yu Hongbing Zhang Samy L. Habib Ronald A. De Pinho Huijuan Liu Baojie Li |
| author_facet |
Dan He Hongguang Wu Jinnan Xiang Xinsen Ruan Peike Peng Yuanyuan Ruan Ye-Guang Chen Yibin Wang Qiang Yu Hongbing Zhang Samy L. Habib Ronald A. De Pinho Huijuan Liu Baojie Li |
| author_sort |
Dan He |
| title |
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway |
| title_short |
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway |
| title_full |
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway |
| title_fullStr |
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway |
| title_full_unstemmed |
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway |
| title_sort |
gut stem cell aging is driven by mtorc1 via a p38 mapk-p53 pathway |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/2b693f1be87a4d81b68d6deb696ecba7 |
| work_keys_str_mv |
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1718389981165125632 |