Antigenic Variation in <italic toggle="yes">Streptococcus pneumoniae</italic> PspC Promotes Immune Escape in the Presence of Variant-Specific Immunity

ABSTRACT Genomic analysis reveals extensive sequence variation and hot spots of recombination in surface proteins of Streptococcus pneumoniae. While this phenomenon is commonly attributed to diversifying selection by host immune responses, there is little mechanistic evidence for the hypothesis that...

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Autores principales: M. Georgieva, L. Kagedan, Ying-Jie Lu, C. M. Thompson, M. Lipsitch
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2018
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Acceso en línea:https://doaj.org/article/2b81aa7c730a496f9fd59a411d7440eb
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