RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

Ras signalling through PI3K kinase has an important role in tumour initiation and progression. Here, the authors show that the interaction of Ras with PI3-Kinase p110α and the subsequent activation of Rac-GTPase impairs cell -cell interaction by blocking the downstream Reelin/E-cadherin, thus result...

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Autores principales: Esther Castellano, Miriam Molina-Arcas, Agata Adelajda Krygowska, Philip East, Patricia Warne, Alastair Nicol, Julian Downward
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/2bae102d12544abe85cdc59962e710f8
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