RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

Ras signalling through PI3K kinase has an important role in tumour initiation and progression. Here, the authors show that the interaction of Ras with PI3-Kinase p110α and the subsequent activation of Rac-GTPase impairs cell -cell interaction by blocking the downstream Reelin/E-cadherin, thus result...

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Autores principales: Esther Castellano, Miriam Molina-Arcas, Agata Adelajda Krygowska, Philip East, Patricia Warne, Alastair Nicol, Julian Downward
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/2bae102d12544abe85cdc59962e710f8
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spelling oai:doaj.org-article:2bae102d12544abe85cdc59962e710f82021-12-02T15:35:18ZRAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression10.1038/ncomms112452041-1723https://doaj.org/article/2bae102d12544abe85cdc59962e710f82016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11245https://doaj.org/toc/2041-1723Ras signalling through PI3K kinase has an important role in tumour initiation and progression. Here, the authors show that the interaction of Ras with PI3-Kinase p110α and the subsequent activation of Rac-GTPase impairs cell -cell interaction by blocking the downstream Reelin/E-cadherin, thus resulting in cell migration.Esther CastellanoMiriam Molina-ArcasAgata Adelajda KrygowskaPhilip EastPatricia WarneAlastair NicolJulian DownwardNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Esther Castellano
Miriam Molina-Arcas
Agata Adelajda Krygowska
Philip East
Patricia Warne
Alastair Nicol
Julian Downward
RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression
description Ras signalling through PI3K kinase has an important role in tumour initiation and progression. Here, the authors show that the interaction of Ras with PI3-Kinase p110α and the subsequent activation of Rac-GTPase impairs cell -cell interaction by blocking the downstream Reelin/E-cadherin, thus resulting in cell migration.
format article
author Esther Castellano
Miriam Molina-Arcas
Agata Adelajda Krygowska
Philip East
Patricia Warne
Alastair Nicol
Julian Downward
author_facet Esther Castellano
Miriam Molina-Arcas
Agata Adelajda Krygowska
Philip East
Patricia Warne
Alastair Nicol
Julian Downward
author_sort Esther Castellano
title RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression
title_short RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression
title_full RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression
title_fullStr RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression
title_full_unstemmed RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression
title_sort ras signalling through pi3-kinase controls cell migration via modulation of reelin expression
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/2bae102d12544abe85cdc59962e710f8
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AT agataadelajdakrygowska rassignallingthroughpi3kinasecontrolscellmigrationviamodulationofreelinexpression
AT philipeast rassignallingthroughpi3kinasecontrolscellmigrationviamodulationofreelinexpression
AT patriciawarne rassignallingthroughpi3kinasecontrolscellmigrationviamodulationofreelinexpression
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AT juliandownward rassignallingthroughpi3kinasecontrolscellmigrationviamodulationofreelinexpression
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