Induction of Premature Cell Senescence Stimulated by High Doses of Antioxidants Is Mediated by Endoplasmic Reticulum Stress

Induction of Premature Cell Senescence Stimulated by High Doses of Antioxidants Is Mediated by Endoplasmic Reticulum Stress

In our previous study, we found that high doses of several substances with antioxidant capacities (Tempol, resveratrol, diphenyleneiodonium) can cause genotoxic stress and induce premature senescence in the human mesenchymal stem cells (MSCs). Here, using whole-transcriptome analysis, we revealed th...

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Bibliographic Details
Main Authors: Olga Lyublinskaya, Julia Kornienko, Julia Ivanova, Natalia Pugovkina, Larisa Alekseenko, Ekaterina Lyublinskaya, Irina Tyuryaeva, Irina Smirnova, Tatiana Grinchuk, Mariia Shorokhova, Anna Krasnenko, Nikolay Plotnikov, Nikolay Nikolsky
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
cell senescence
stress-induced senescence
antioxidants
mesenchymal stem cells
reductive stress
endoplasmic reticulum stress
Biology (General)
QH301-705.5
Chemistry
QD1-999
Online Access:https://doaj.org/article/2bb5b475aa274a41ac824af60f4f5b86
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https://doaj.org/article/2bb5b475aa274a41ac824af60f4f5b86

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