The activated ATM/p53 pathway promotes autophagy in response to oxidative stress-mediated DNA damage induced by Microcystin-LR in male germ cells

The activated ATM/p53 pathway promotes autophagy in response to oxidative stress-mediated DNA damage induced by Microcystin-LR in male germ cells

Microcystin-LR (MC-LR) is an intracellular toxin with multi-organ toxicity and the testis is one of its important target organs. Although there is increasing research on MC-LR in male reproductive toxicity, the association between DNA damage and autophagy induced by MC-LR in male germ cells are stil...

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Détails bibliographiques
Auteurs principaux: Zhihui Tian, Haohao Liu, Xinghai Chen, Michael D. Losiewicz, Rui Wang, Xingde Du, Bingqian Wang, Ya Ma, Shiyu Zhang, Linjia Shi, Xing Guo, Yongshui Wang, Bingyu Zhang, Shumeng Yuan, Xin Zeng, Huizhen Zhang
Format: article
Langue:EN
Publié: Elsevier 2021
Sujets:
Microcystin-LR
Reproductive toxicity
DNA damage
ATM
Autophagy
Oxidative stress
Environmental pollution
TD172-193.5
Environmental sciences
GE1-350
Accès en ligne:https://doaj.org/article/2bde358b27514e6ca45bc28180cfbc4c
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https://doaj.org/article/2bde358b27514e6ca45bc28180cfbc4c

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