The activated ATM/p53 pathway promotes autophagy in response to oxidative stress-mediated DNA damage induced by Microcystin-LR in male germ cells

The activated ATM/p53 pathway promotes autophagy in response to oxidative stress-mediated DNA damage induced by Microcystin-LR in male germ cells

Microcystin-LR (MC-LR) is an intracellular toxin with multi-organ toxicity and the testis is one of its important target organs. Although there is increasing research on MC-LR in male reproductive toxicity, the association between DNA damage and autophagy induced by MC-LR in male germ cells are stil...

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Detalles Bibliográficos
Autores principales: Zhihui Tian, Haohao Liu, Xinghai Chen, Michael D. Losiewicz, Rui Wang, Xingde Du, Bingqian Wang, Ya Ma, Shiyu Zhang, Linjia Shi, Xing Guo, Yongshui Wang, Bingyu Zhang, Shumeng Yuan, Xin Zeng, Huizhen Zhang
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
Microcystin-LR
Reproductive toxicity
DNA damage
ATM
Autophagy
Oxidative stress
Environmental pollution
TD172-193.5
Environmental sciences
GE1-350
Acceso en línea:https://doaj.org/article/2bde358b27514e6ca45bc28180cfbc4c
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https://doaj.org/article/2bde358b27514e6ca45bc28180cfbc4c

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