Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel

Gating of the central pore in voltage-dependent ion channels is mediated by changes in membrane potential. Here, the authors use substituted cysteine accessibility and metal cross-bridging to identify gate residues that form a physical occlusion when closed in a eukaryotic voltage-gated sodium chann...

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Autores principales: Kevin Oelstrom, Baron Chanda
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Q
Acceso en línea:https://doaj.org/article/2bec79958cb7492980f8567748506534
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