Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel

Gating of the central pore in voltage-dependent ion channels is mediated by changes in membrane potential. Here, the authors use substituted cysteine accessibility and metal cross-bridging to identify gate residues that form a physical occlusion when closed in a eukaryotic voltage-gated sodium chann...

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Autores principales:	Kevin Oelstrom, Baron Chanda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2bec79958cb7492980f8567748506534
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spelling	oai:doaj.org-article:2bec79958cb7492980f85677485065342021-12-02T17:31:51ZCongruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel10.1038/ncomms116082041-1723https://doaj.org/article/2bec79958cb7492980f85677485065342016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11608https://doaj.org/toc/2041-1723Gating of the central pore in voltage-dependent ion channels is mediated by changes in membrane potential. Here, the authors use substituted cysteine accessibility and metal cross-bridging to identify gate residues that form a physical occlusion when closed in a eukaryotic voltage-gated sodium channel.Kevin OelstromBaron ChandaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin Oelstrom Baron Chanda Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel
description	Gating of the central pore in voltage-dependent ion channels is mediated by changes in membrane potential. Here, the authors use substituted cysteine accessibility and metal cross-bridging to identify gate residues that form a physical occlusion when closed in a eukaryotic voltage-gated sodium channel.
format	article
author	Kevin Oelstrom Baron Chanda
author_facet	Kevin Oelstrom Baron Chanda
author_sort	Kevin Oelstrom
title	Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel
title_short	Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel
title_full	Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel
title_fullStr	Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel
title_full_unstemmed	Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel
title_sort	congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2bec79958cb7492980f8567748506534
work_keys_str_mv	AT kevinoelstrom congruentpatternofaccessibilityidentifiesminimalporegateinanonsymmetricvoltagegatedsodiumchannel AT baronchanda congruentpatternofaccessibilityidentifiesminimalporegateinanonsymmetricvoltagegatedsodiumchannel
_version_	1718380479861751808

Congruent pattern of accessibility identifies minimal pore gate in a non-symmetric voltage-gated sodium channel

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