Interphase human chromosome exhibits out of equilibrium glassy dynamics

The 3D organization of chromosomes within the nuclear space is important for biological functions. Here the authors model chromosomes as self-avoiding copolymers with distinct epigenetic states, and show that the features of experimentally generated contact maps can be reproduced and their dynamics...

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Autores principales: Guang Shi, Lei Liu, Changbong Hyeon, D. Thirumalai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/2c075397a936435897898578df34c653
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