Interphase human chromosome exhibits out of equilibrium glassy dynamics

The 3D organization of chromosomes within the nuclear space is important for biological functions. Here the authors model chromosomes as self-avoiding copolymers with distinct epigenetic states, and show that the features of experimentally generated contact maps can be reproduced and their dynamics...

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Autores principales:	Guang Shi, Lei Liu, Changbong Hyeon, D. Thirumalai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c075397a936435897898578df34c653
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spelling	oai:doaj.org-article:2c075397a936435897898578df34c6532021-12-02T15:33:46ZInterphase human chromosome exhibits out of equilibrium glassy dynamics10.1038/s41467-018-05606-62041-1723https://doaj.org/article/2c075397a936435897898578df34c6532018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05606-6https://doaj.org/toc/2041-1723The 3D organization of chromosomes within the nuclear space is important for biological functions. Here the authors model chromosomes as self-avoiding copolymers with distinct epigenetic states, and show that the features of experimentally generated contact maps can be reproduced and their dynamics predicted.Guang ShiLei LiuChangbong HyeonD. ThirumalaiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guang Shi Lei Liu Changbong Hyeon D. Thirumalai Interphase human chromosome exhibits out of equilibrium glassy dynamics
description	The 3D organization of chromosomes within the nuclear space is important for biological functions. Here the authors model chromosomes as self-avoiding copolymers with distinct epigenetic states, and show that the features of experimentally generated contact maps can be reproduced and their dynamics predicted.
format	article
author	Guang Shi Lei Liu Changbong Hyeon D. Thirumalai
author_facet	Guang Shi Lei Liu Changbong Hyeon D. Thirumalai
author_sort	Guang Shi
title	Interphase human chromosome exhibits out of equilibrium glassy dynamics
title_short	Interphase human chromosome exhibits out of equilibrium glassy dynamics
title_full	Interphase human chromosome exhibits out of equilibrium glassy dynamics
title_fullStr	Interphase human chromosome exhibits out of equilibrium glassy dynamics
title_full_unstemmed	Interphase human chromosome exhibits out of equilibrium glassy dynamics
title_sort	interphase human chromosome exhibits out of equilibrium glassy dynamics
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2c075397a936435897898578df34c653
work_keys_str_mv	AT guangshi interphasehumanchromosomeexhibitsoutofequilibriumglassydynamics AT leiliu interphasehumanchromosomeexhibitsoutofequilibriumglassydynamics AT changbonghyeon interphasehumanchromosomeexhibitsoutofequilibriumglassydynamics AT dthirumalai interphasehumanchromosomeexhibitsoutofequilibriumglassydynamics
_version_	1718387012668489728

Interphase human chromosome exhibits out of equilibrium glassy dynamics

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