Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1
Neuropilin-1 (Nrp-1) is a marker for CD4 + regulatory T cells. Here the authors show that Nrp-1 is co-expressed with PD-1 on a subset of CD8 tumour-infiltrating T lymphocytes and inhibits T-cell migration and cytotoxicity when bound by its ligand semaphorin-3A, while blockade of Nrp-1 synergises wit...
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| Main Authors: | , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2019
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| Subjects: | |
| Online Access: | https://doaj.org/article/2c3cddaf2f6c490e988bea7275b3ada4 |
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