Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins

Some phages carry genes coding for anti-CRISPR (Acr) proteins that interfere with the activity of bacterial CRISPR-Cas systems. Here, Hynes et al. characterize a new Acr family from streptococcal phages and investigate its potential in genome-editing applications.

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Auteurs principaux:	Alexander P. Hynes, Geneviève M. Rousseau, Daniel Agudelo, Adeline Goulet, Beatrice Amigues, Jeremy Loehr, Dennis A. Romero, Christophe Fremaux, Philippe Horvath, Yannick Doyon, Christian Cambillau, Sylvain Moineau
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/2c460a63a313487ab66f065d9084faaf
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spelling	oai:doaj.org-article:2c460a63a313487ab66f065d9084faaf2021-12-02T16:50:07ZWidespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins10.1038/s41467-018-05092-w2041-1723https://doaj.org/article/2c460a63a313487ab66f065d9084faaf2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05092-whttps://doaj.org/toc/2041-1723Some phages carry genes coding for anti-CRISPR (Acr) proteins that interfere with the activity of bacterial CRISPR-Cas systems. Here, Hynes et al. characterize a new Acr family from streptococcal phages and investigate its potential in genome-editing applications.Alexander P. HynesGeneviève M. RousseauDaniel AgudeloAdeline GouletBeatrice AmiguesJeremy LoehrDennis A. RomeroChristophe FremauxPhilippe HorvathYannick DoyonChristian CambillauSylvain MoineauNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander P. Hynes Geneviève M. Rousseau Daniel Agudelo Adeline Goulet Beatrice Amigues Jeremy Loehr Dennis A. Romero Christophe Fremaux Philippe Horvath Yannick Doyon Christian Cambillau Sylvain Moineau Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins
description	Some phages carry genes coding for anti-CRISPR (Acr) proteins that interfere with the activity of bacterial CRISPR-Cas systems. Here, Hynes et al. characterize a new Acr family from streptococcal phages and investigate its potential in genome-editing applications.
format	article
author	Alexander P. Hynes Geneviève M. Rousseau Daniel Agudelo Adeline Goulet Beatrice Amigues Jeremy Loehr Dennis A. Romero Christophe Fremaux Philippe Horvath Yannick Doyon Christian Cambillau Sylvain Moineau
author_facet	Alexander P. Hynes Geneviève M. Rousseau Daniel Agudelo Adeline Goulet Beatrice Amigues Jeremy Loehr Dennis A. Romero Christophe Fremaux Philippe Horvath Yannick Doyon Christian Cambillau Sylvain Moineau
author_sort	Alexander P. Hynes
title	Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins
title_short	Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins
title_full	Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins
title_fullStr	Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins
title_full_unstemmed	Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins
title_sort	widespread anti-crispr proteins in virulent bacteriophages inhibit a range of cas9 proteins
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2c460a63a313487ab66f065d9084faaf
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Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins

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