IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of <named-content content-type="genus-species">Legionella pneumophila</named-content>

IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of <named-content content-type="genus-species">Legionella pneumophila</named-content>

ABSTRACT Interferon gamma (IFN-γ) restricts the intracellular replication of many pathogens, but the mechanism by which IFN-γ confers cell-intrinsic pathogen resistance remains unclear. For example, intracellular replication of the bacterial pathogen Legionella pneumophila in macrophages is potently...

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Bibliographic Details
Main Authors: Jordan V. Price, Daniel Russo, Daisy X. Ji, Roberto A. Chavez, Lucian DiPeso, Angus Yiu-Fai Lee, Jörn Coers, Russell E. Vance
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
Legionella pneumophila
host-pathogen interactions
innate immunity
interferons
macrophages
Microbiology
QR1-502
Online Access:https://doaj.org/article/2c4aa12c2d0e48f185f4175d317f39e4
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